The Effect of 12 Weeks Aerobic Training on Expression of AKT1 and mTORc1 genes in the Left Ventricle of Type 2 Diabetic Rats

Objective: The purpose of this study was to investigate the effect of 12 weeks aerobic training on the expression of AKT1 and mTORc1 genes in the left ventricle of T2DM rats. Materials and Methods: The statistical sample consisted of 21 male wistar rats from the Pasteur Institute in Tehran. (10 weeks old weighing 220 ± 20 grams). They were divided into three groups: diabetic aerobic training, diabetic control and healthy control groups. The diabetic aerobic training group participated in a period of aerobic training for 12 weeks in 5 sessions per week with gradual increase in speed (18-26 m / min) and 10 to 55 minutes in the form of running on treadmill. AKT1 mRNA and mTORc1 mRNA were evaluated by RT-Real time PCR technique by the Roturer 6000 system. Results: According ANOVA findings diabetics rat significantly alters the expression of Akt1 (P-value: 0.002) and mTORc1 (P-value: 0.001). However, aerobic exercise significantly increase the expression of Akt1 (P-value: 0.002) and mTORc1 (P-value: 0.001) in comparison with the diabetic untrained control groups. Conclusion: Although this study was conducted on animals and it was necessary to caution people in generalizing these findings, it seems that an aerobic training period with an increase in the expression of Akt1 and mTORc1 genes leads to improved cardiac function and it prevents heart disease from diabetes.